Aptamer‐Conjugated Biocompatible Nanospheres for Fluorescent Imaging–Guided Hepatocellular Carcinoma–Targeted Phototherapeutic Modality

Conventional strategies against hepatocellular carcinoma (HCC) remain unsatisfactory due to its invasiveness and poor prognosis. Herein, it is utmost imperative require alternative modalities with less invasiveness, good clinical efficacy, low side effects. A combination of photothermal therapy (PTT) photodynamic (PDT) an emerging modality refractory HCC. To date a majority PTT/PDT paradigms has disappointing therapeutic efficiency, owing targeting ability nanotheranostic agents or imprecise irradiation lasers. In this study, HCC-specific aptamer chlorine e6 (Ce6)-modified polydopamine (PDA) nanospheres decoration Pt quantum dots (termed [email protected] bioconjugates) are explored combat HCC in vivo by synergy PTT PDT modalities. The bioconjugates can effectively accumulate into tumor sites specifically binding Glypican-3 (GPC3)-positive cells, core PDA exerts strong optical absorption near-infrared (NIR) region enable performance. Meanwhile, the moieties Ce6 subsequently serve as photosensitizers fluorophores generate reactive oxygen species (ROS) guide phototherapeutics, respectively. current study finally suggests that act protocol for programmable ablation believed will have significant impact on translation promising therapy.